Hideki Hasegawa Selected Research

Secretory Immunoglobulin A (SIgA)

1/2021	An influenza HA stalk reactive polymeric IgA antibody exhibits anti-viral function regulated by binary interaction between HA and the antibody.
1/2019	CpG ODN G9.1 as a novel nasal ODN adjuvant elicits complete protection from influenza virus infection without causing inflammatory immune responses.
1/2019	IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody.
7/2017	Intranasal Administration of Whole Inactivated Influenza Virus Vaccine as a Promising Influenza Vaccine Candidate.
1/2017	The road to a more effective influenza vaccine: Up to date studies and future prospects.
6/2015	Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus.
2/2009	Development of mucosal adjuvants for intranasal vaccine for H5N1 influenza viruses.

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Hideki Hasegawa Research Topics

Disease

75	Infections 07/2022 - 03/2002
40	Human Influenza (Influenza) 07/2022 - 06/2003
17	Virus Diseases (Viral Diseases) 02/2022 - 01/2002
10	COVID-19 10/2022 - 01/2020
7	Pneumonia (Pneumonitis) 01/2020 - 06/2003
6	Neoplasms (Cancer) 06/2021 - 05/2003
6	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 01/2021 - 04/2006
6	Lymphoma (Lymphomas) 12/2020 - 10/2004
5	Body Weight (Weight, Body) 01/2022 - 03/2009
4	Severe Fever with Thrombocytopenia Syndrome 01/2022 - 01/2016
4	Inflammation (Inflammations) 01/2021 - 03/2009
3	Influenza in Birds (Avian Flu) 07/2022 - 01/2013
3	Severe Acute Respiratory Syndrome 01/2022 - 06/2005
3	Leukemia 01/2021 - 12/2010
3	Progressive Multifocal Leukoencephalopathy 01/2020 - 09/2012
3	Encephalitis (Encephalitis, Rasmussen) 02/2017 - 03/2013
3	Acquired Immunodeficiency Syndrome (AIDS) 01/2017 - 06/2012
3	Asthma (Bronchial Asthma) 01/2017 - 08/2013
3	Type 2 Diabetes Mellitus (MODY) 01/2014 - 03/2008
2	Coronavirus Infections 01/2020 - 01/2019
2	Anemia 09/2019 - 01/2011
2	Lymphadenitis (Adenitis) 04/2018 - 11/2014
2	Mpox (monkeypox) 07/2017 - 06/2006
2	Viremia 07/2017 - 01/2014
2	Sepsis (Septicemia) 03/2017 - 01/2014
2	Disease Progression 02/2017 - 01/2010
2	Communicable Diseases (Infectious Diseases) 07/2014 - 02/2009
2	Vaccinia 08/2006 - 09/2005
2	Smallpox (Variola) 06/2006 - 09/2005

Drug/Important Bio-Agent (IBA)

46	VaccinesIBA 02/2022 - 03/2002
21	Immunoglobulin A (IgA)IBA 01/2021 - 01/2002
20	AntibodiesIBA 10/2022 - 01/2002
16	Immunoglobulin G (IgG)IBA 01/2021 - 01/2002
15	Hemagglutinins (Hemagglutinin)IBA 01/2021 - 06/2003
12	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2006
12	AntigensIBA 12/2021 - 08/2003
10	Antiviral Agents (Antivirals)IBA 10/2022 - 01/2018
10	Influenza Vaccines (Influenza Vaccine)FDA Link 04/2020 - 01/2002
10	CytokinesIBA 01/2017 - 09/2006
7	Secretory Immunoglobulin A (SIgA)IBA 01/2021 - 02/2009
6	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 07/2003
5	Neutralizing AntibodiesIBA 01/2022 - 02/2009
5	Inactivated VaccinesIBA 04/2020 - 11/2008
5	Interleukin-6 (Interleukin 6)IBA 01/2017 - 02/2009
5	ChemokinesIBA 01/2014 - 09/2006
4	baloxavirIBA 07/2022 - 11/2019
4	Monoclonal AntibodiesIBA 02/2022 - 01/2011
4	Messenger RNA (mRNA)IBA 01/2022 - 09/2006
4	Poly I-CIBA 09/2020 - 03/2005
4	MicroRNAs (MicroRNA)IBA 01/2020 - 01/2016
4	ParaffinIBA 02/2015 - 08/2003
4	Combined VaccinesIBA 10/2010 - 01/2002
3	N-methyl-valyl-amiclenomycin (BA 2)IBA 02/2022 - 01/2022
3	N-(2-cyanoethylene)urea (BA 1)IBA 02/2022 - 01/2022
3	Biomarkers (Surrogate Marker)IBA 10/2021 - 01/2011
3	Viral ProteinsIBA 06/2021 - 01/2010
3	DiamondIBA 01/2021 - 01/2020
3	Interleukin-10 (Interleukin 10)IBA 01/2021 - 06/2008
3	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 04/2006
3	Double-Stranded RNA (RNA, Double Stranded)IBA 09/2020 - 03/2005
3	NucleoproteinsIBA 09/2019 - 01/2012
3	RNA (Ribonucleic Acid)IBA 01/2019 - 01/2010
3	Formaldehyde (Formol)FDA Link 03/2013 - 08/2003
2	favipiravirIBA 07/2022 - 01/2016
2	peramivirIBA 07/2022 - 09/2020
2	COV2-2196IBA 02/2022 - 01/2022
2	molnupiravirIBA 02/2022 - 01/2022
2	nirmatrelvirIBA 02/2022 - 01/2022
2	COV2-2130IBA 02/2022 - 01/2022
2	aluminum sulfate (alum)IBA 01/2022 - 01/2019
2	Amino Acids FDA Link 01/2021 - 06/2014
2	Glycoproteins (Glycoprotein)IBA 01/2021 - 01/2018
2	Poly IIBA 09/2020 - 09/2007
2	Viral AntigensIBA 01/2020 - 10/2019
2	GoldIBA 01/2020 - 05/2018
2	Biological ProductsIBA 01/2020 - 03/2017
2	EnzymesIBA 01/2019 - 04/2018
2	Nucleocapsid ProteinsIBA 04/2018 - 04/2016
2	bu-zhong-yi-qi-tangIBA 01/2017 - 01/2013
2	Interleukin-13IBA 08/2013 - 06/2008
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2013 - 06/2008
2	InterleukinsIBA 08/2013 - 06/2008
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2013 - 11/2008
2	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2013 - 11/2008
2	GTP-Binding Proteins (G-Protein)IBA 01/2013 - 01/2011
2	poly(I).poly(c12,U) (ampligen)IBA 10/2009 - 09/2007
2	Toll-Like Receptor 3IBA 10/2009 - 09/2007
2	Smallpox Vaccine (Vaccine, Smallpox)FDA Link 03/2008 - 06/2006
2	ChitinIBA 06/2007 - 01/2005
2	Cytidine Monophosphate (CMP)IBA 10/2006 - 01/2005
1	laninamivirIBA 07/2022
1	Amantadine (Aman)FDA LinkGeneric 07/2022
1	Neuraminidase (Sialidase)IBA 07/2022
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 07/2022
1	Oseltamivir (Tamiflu)FDA Link 07/2022
1	Zanamivir (Relenza)FDA Link 07/2022

Therapy/Procedure

8	Intranasal Administration 11/2015 - 01/2002
6	Therapeutics 01/2019 - 04/2006
2	Injections 07/2017 - 01/2017
1	Plasma Exchange 01/2022